I'm about to start setting up the distro as well. Since fidelity is not really an issue in the additional zones I'm using self-powered PC speakers in the kitchen and basement. One set Altec Lansing 2.1 and one set Boston Acoustics 2.1
My intention is to use STP (shielded twisted pair) with standard 1/8" jacks at the ends. I don't yet have the STP but should you go with a "custom" wired solution here's some info from an electrical engineer with amp building experience:
1: Use shielded cable,
2: there IS twisted pair specifically for line level transmission, but ethernet STP can do the job be sure to put a channel and its ground on the same pair
3: ground the shield seperately from the audio grounds
4: ground the shield AT ONE END! (make sure you can easily switch the grounding to either end) with PC speakers you want the ground on the PC chassis
Think that covers it. If I can make any progress on my own setup, I'll post it here. My 1yr old makes things.... slow