Ofcourse it's possible, and it's petty easy.
Press F2 to get config window. Go to events section. Create new event. Assign it from right hand side, os->execute file, then click browse to find the exe file, and click add button to asign that to created event. Exit from config, press pause to get editor, slect button to run the program, click event tab, and select just created event to assign it to that button.
Voila!
D.